The GEnetics of Nephropathy – anĀ International Effort consortium assembles investigators at the Massachusetts General Hospital, Boston Children’s Hospital and Broad Institute in Boston, the University of Helsinki, Queen’s University Belfast, University College Dublin, the University of Michigan and the University of Pennsylvania to discover genetic determinants of diabetic kidney disease (D). It catalyzed the formation of the JDRF-funded Diabetic Nephropathy Collaborative Research Initiative, which has aggregated the largest collection of DKD cases and controls with type 1 diabetes in the world. The Florez and Hirschhorn labs lead the efforts of a genome-wide association and exome chip study in 18,000 cases and controls. The original GENIE publication can be found here.

Genetic Discovery