To achieve these objectives, our research covers the entire arc from fundamental genetic discovery to clinical application. Our multidisciplinary team focuses on the following set of activities:
The road from genetic association to molecular mechanism is arduous. Once a genomic region is identified as relevant to disease, functional experiments are carried out in relevant model systems to understand how a nucleotide change leads to metabolic changes. Specific projects are described here.
Our diverse team is composed of basic biologists, human geneticists, statistical analysts, computational scientists, software engineers, clinical research coordinators, and physician scientists.
We collaborate with many colleaguesÂ around the world to advance the genetics of type 2 diabetes and conduct research that will ideally enable clinicians to personalize therapy to treat their patients.
Our group unites a premier academic hospital with a leading genomics institute, in a seamless arrangement that straddles both institutions. We are situatedÂ in the MGH Center for Genomic Medicine on the 5th floor of the Simches Research Building in the MGH main campus, and in the Diabetes Research Group of the Programs in Metabolism and Medical & Population Genetics , on the 10th floor of the Broad Institute.