SUGAR-MGH logoSUGAR-MGH: Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans

We are seeking research volunteers to study the influence of inherited genes on the response to two very common type 2 diabetes medications, Metformin and Glipizide.  You might be eligible if you are:

  • over the age of 18 years
  • either healthy OR have diabetes but are not currently on diabetes medication,
  •  may be at risk for diabetes (risk factors include having high or “borderline-high” blood sugars, being overweight, having a history of gestational diabetes (diabetes during pregnancy), being an ethnic minority, or having a first degree relative with type 2 diabetes).

The study involves two visits to the Massachusetts General Hospital one week apart. The first visit takes about 5 hours and the second about 3 hours.  As part of the study you will be asked to take one of these medications at each visit and will also be given a sugar drink.  Blood will be drawn at both visits.  Participants will receive monetary compensation, parking vouchers or reimbursement for public transportation and a free meal

If you are interested or want more information about SUGAR-MGH, please contact us:

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