Original Reports

    • “TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.  N Engl J Med 2006;355:241-250. (PMID: 16855264).
    • Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PF, D’Agostino RB, Cupples LA.  Genotype score in addition to common risk factors for prediction of type 2 diabetes.  N Engl J Med 2008;359:2208-2219. (PMID: 19020323).
    • Dupuis J*, Langenberg C*, Prokopenko I*, Saxena R*, Soranzo N*, (…), Boehnke M†, McCarthy MI†, Florez JC† and Barroso I† for the MAGIC investigators. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010;42:105-116. (PMID: 20081858).
    • Ingelsson E*†, Langenberg C*, Hivert M-F*, (…), Groop L†, Watanabe RM†, Florez JC† on behalf of the MAGIC investigators. Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans.  Diabetes 2010;59:1266-1275. (PMID: 20185807).
    • Jablonski KA, McAteer JB, de Bakker PIW, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC for the Diabetes Prevention Program Research Group.  Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle interventions in the Diabetes Prevention Program.  Diabetes 2010;59:2672-2681. (PMID: 20682687).
    • Hivert M-F, Jablonski KA, Perreault L, Saxena R, McAteer JB, Franks PW, Hamman RF, Kahn SE, Haffner S, the DIAGRAM Consortium, Meigs JB, Altshuler D, Knowler WC, Florez JC for the Diabetes Prevention Program Research Group.  An updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the Diabetes Prevention Program.  Diabetes 2011;60:1340-1348. (PMID: 21378175).
    • Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Palma M, Hardy G, Kristo F, Palma A, Fox CS, Jacques PF, Fernandez C, O’Donnell CJ, Carr SA, Mootha SK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE.  Metabolite profiles and the risk of developing diabetes.  Nat Med 2011;17:448-453. (PMID: 21423183).
    • Strawbridge RJ*, Dupuis J*, Prokopenko I*, Barker A*, Ahlqvist E*, (…), Langenberg C†, Hamsten A†, Florez JC†.  Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.  Diabetes 2011;60:2624-2634. (PMID: 21873549).
    • Walford GA, Green T, Neale B, Isakova T, Rotter JI, Grant SFA, Fox CS, Pankow JS, Wilson JG, Meigs JB, Siscovick DS, Bowden DW, Daly MJ, Florez JC.  Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism.  Diabetologia 2012;55:331-339. (PMID: 22038522).
    • Florez JC, Jablonski KA, Taylor A, Mather K, Horton E, White NH, Barrett-Connor E, Knowler WC, Shuldiner AR, Pollin TI for the Diabetes Prevention Program Research Group.  The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.  Diabetes Care 2012;35:1864-1867. (PMID: 22751958).
    • Billings LK, Hsu YH, Ackerman RJ, Dupuis J, Voight BF, Rasmussen-Torvik LJ, Hercberg S, Lathrop M, Barnes D, Langenberg C, Hui J, Fu M, Bouatia-Naji N, Lecoeur C, An P, Magnusson PK, Surakka I, Ripatti S, Christiansen L, Dalgård C, Folkersen L, Grundberg E, the MAGIC Investigators, the DIAGRAM + Consortium, the MuTHER Consortium, the ASCOT Investigators, the GEFOS Consortium, Eriksson P, Kaprio J, Ohm Kyvik K, Pedersen NL, Borecki IB, Province MA, Balkau B, Froguel P, Shuldiner AR, Palmer LJ, Wareham N, Meneton P, Johnson T, Pankow JS, Karasik D, Meigs JB, Kiel DP, Florez JC.  Impact of common variation in bone-related genes on type 2 diabetes and related traits.  Diabetes 2012;61:2176-2186. (PMID: 22698912).
    • Sandholm N*, Salem RM*, McKnight AJ*, Brennan EP*, (…), Hirschhorn JN†, Godson C†, Florez JC†, Groop PH† and Maxwell AP†.  New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet 2012;8:e1002921. (PMID: 23028342).
    • Grant RW, O’Brien KE, Waxler JL, Vassy JL, Delahanty LM, Bissett LG, Green RC, Stember KG, Guiducci C, Park ER, Florez JC, Meigs JB.  Personalized genetic risk counseling to motivate diabetes prevention: A randomized trial. Diabetes Care 2013;36:13-19.  (PMID: 22933432).

Reviews and Chapters

    • Florez JC, Hirschhorn JN, Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics and Hum Genet 2003;4:257-291. (PMID: 14527304).
    • Florez JC.  Newly identified loci highlight beta-cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?  Diabetologia 2008;51:110-1110. (PMID: 18504548).
    • Stolerman ES, Florez JC.  Genomics of type 2 diabetes mellitus: implications for the clinician.  Nat Rev Endocrinol 2009;5:429-436. (PMID: 19564886).
    • Billings LK, Florez JC.  The genetics of type 2 diabetes: What have we learned from GWAS?  Ann NY Acad Sci 2010;1212:59-77. (PMID: 21091714).
    • Huang C, Florez JC.  Pharmacogenetics in type 2 diabetes: potential implications for clinical practice.  Genome Med 2011;3:76. (PMID: 22126607).
  (*) These authors contributed equally to this work
  (†) Co-corresponding authors

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