Dr. Jose Florez, M.D., Ph.D.


20141007_florezlabgrbmw_051Jose C. Florez, M.D., Ph.D. is an Associate Physician in Medicine (Endocrine Division) at the Massachusetts General Hospital, an Associate Professor at Harvard Medical School, and an Associate Member at the Broad Institute, where he is active in the Program in Medical and Population Genetics and the Broad Metabolism Initiative.

He and his group have contributed to the performance and analysis of genome-wide association studies in type 2 diabetes and related traits, in the Diabetes Genetics Initiative (formed by the Broad Institute, Lund University and Novartis), the Framingham Heart Study, and other international consortia such as MAGIC, GENIE, DIAGRAM and SIGMA.  He leads the genetic research efforts of the Diabetes Prevention Program, where the effects of genetic variants on the development of diabetes can be examined prospectively, and their impact on specific behavioral and pharmacological preventive interventions can be assessed.  He is the Principal Investigator of the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGARMGH), and also conducts other pharmacogenetic studies at MGH.  He is an author on 110+ original publications and 35+ reviews/book chapters.

In addition to his research and teaching duties, he is clinically active in the MGH Diabetes Center, the Endocrine inpatient consult service, and the Down Syndrome Program.  He serves on the Editorial Boards for Human Genetics and the Journal of Clinical Endocrinology and Metabolism, and has been on Editorial Boards for Diabetes and Diabetologia; he is also the Editor-in-Chief for Current Diabetes Reports.  He is the recipient of the MGH Physician Scientist Development Award, a Doris Duke Charitable Foundation Clinical Scientist Development Award, the MGH Department of Medicine Stephen Krane Award, the MGH Research Scholars Award, and the 2010 Presidential Early Career Award for Scientists and Engineers, the highest honor bestowed by the United States government on science and engineering professionals in the early stages of their independent research careers.